Information contained on this page is provided by companies via press release distributed through PR Newswire, an independent third-party content provider. PR Newswire, WorldNow and this Station make no warranties or representations in connection therewith.
SOURCE Cerecor Inc
BALTIMORE, March 20, 2013 /PRNewswire/ -- Cerecor Inc, a neuroscience biotech company that develops therapies that have the potential to make a difference in diseases with high unmet medical needs, today announced that it has acquired exclusive, worldwide rights to develop, register and commercialize agents that inhibit catechol-O-methyltransferase inhibitors ("COMT inhibitors"), previously discovered and owned by Merck, known as MSD outside the United States and Canada.
COMT is an enzyme that breaks down dopamine, a neurotransmitter that plays a key role in higher brain functions such as motivation, cognition and emotion. Drugs that inhibit COMT have been used to treat patients with Parkinson's disease; however, they have poor brain penetration and limited safety and tolerability. COMT inhibition also has broad potential applicability in other CNS diseases, such as addictive behaviors and schizophrenia, by specifically increasing dopamine levels in areas of the brain affected by these conditions. While the development of schizophrenia drugs to date has focused on reducing psychosis, improvement in functional outcome has been largely unattainable because current drugs do not have clinically significant impact on the "negative symptoms" and cognitive impairment of the disease. Drugs that inhibit COMT improve working memory and other measures of cognitive function in animals and in clinical studies (normal subjects and in schizophrenics).
"Merck has developed an innovative COMT platform that has addressed the toxicity associated with existing COMT drugs. By accessing this platform, Cerecor broadens its cognition pipeline, which also includes DAAO inhibitors. This enhances our leadership in neuropsychiatric drug development," stated Dr. Reza Mazhari, Cerecor's VP of Drug Discovery and Development.
Under the terms of the agreement, Cerecor will evaluate more than 2,000 molecules and select lead candidates for clinical development. Consideration includes milestone payments and royalties consistent with other preclinical licenses in neuroscience. Cerecor anticipates completing the technology transfer activities in 2013.
"Adding COMT inhibitors to our drug development portfolio enhances our mission. Cerecor continues to focus on targets or technologies that have demonstrated human proof of concept, and for which biomarkers could be used to steer early clinical development. We are delighted that Merck has chosen Cerecor to help realize the value of such an innovative body of work as contained within their COMT patent portfolio," added Dr. Blake Paterson, Cerecor's co-founder and CEO.
"Cerecor's approach to the development of safe and effective therapies, combined with its experienced management team, makes them ideally suited to help advance this platform targeted for the treatment of CNS diseases," said Dr. Richard Hargreaves, Vice President, Worldwide Head of Basic Research, Neuroscience, Merck Research Laboratories.
Cerecor Inc is a biopharmaceutical company focused on the discovery, development and commercialization of prescription pharmaceuticals whose primary activity is in the human nervous system. We are a Delaware corporation, based in Baltimore and co-founded in April 2011 by Drs. Solomon Snyder, Barbara Slusher, Blake Paterson and Mr. Isaac Blech. Cerecor is focused on translational medicine – the accelerated transfer of technology from the laboratory to early human trials, with the mission of commercializing therapeutics that make a difference.
By: Brittany Paris firstname.lastname@example.org Hundreds of water bottles, chips, juice boxes and bug spray were all packed up into one car, ready to be sent to Oklahoma. It was donated by the Pyrtle ElementaryMore >>
Hundreds of water bottles, chips, juice boxes and bug spray were all packed up into one car, ready to be sent to Oklahoma. It was donated by the Pyrtle Elementary School 5th graders.More >>
Posted By: KLKN Newsroom email@example.com The Nebraska Association of School Boards is collecting donations to deliver to victims of the tornado in Moore, Oklahoma. NASB Executive Director John Spatz saysMore >>
The Nebraska Association of School Boards collected donations to deliver to victims of the tornado in Moore, Oklahoma.More >>
Posted By: KLKN Newsroom firstname.lastname@example.org AAA says relief at the pumps is coming soon! After climbing 50 cents a gallon in just two weeks, AAA says that unleaded fuel prices in Nebraska should retreatMore >>
AAA says relief at the pumps is coming soon! More >>
Posted By: KLKN Newsroom email@example.com The Lancaster County Sheriff's Office is looking for a missing 17-year-old girl. Chief Deputy Jeff Bliemeister says Lisa Van Meveren was last seen at her family'sMore >>
The Lancaster County Sheriff's Office have found a missing 17-year-old girl.More >>
Posted By: Dan Messineo firstname.lastname@example.org A local pageant winner is on a mission. She wants to spread hope to those with mental health disorders. Miss Gering, Kaylee Carlberg, encourages thoseMore >>
A local pageant winner is on a mission. She wants to spread hope to those with mental health disorders.More >>
By: Megan Palera email@example.com Imagine and EF-5 tornado coming right at you. It did to a Lincoln man coming home from Texas. It was a 200 mph monster that Luke Dierking never thought he would see.More >>
A Lincoln man captures the Okla. tornado on camera as he heads home from Texas.More >>
By: Bill Schammert firstname.lastname@example.org Two dozen dead, including nine children, hundreds more injured. They're the statistics nobody likes to hear. But, as University of Nebraska-Lincoln climatologist,More >>
Two dozen dead, including nine children, hundreds more injured. They're the statistics nobody likes to hear. But, as University of Nebraska-Lincoln climatologist, Dr. Ken Dewey, tells us, this tornado is eerily similar to what happened in Lancaster Co., in 2004.More >>