COVID boosters 46 times more likely to prevent hospitalizations

According to data from DHHS

LINCOLN, Neb. (KLKN) – According to an analysis from the Nebraska Department of Health and Human Services (DHHS) individuals who received their first round of the COVID-19 vaccine are 11 times less likely to be hospitalized.

State Epidemiologist Dr. Matthew Donahue and his team ran an analysis over the course of 2021 to determine hospitalizations and deaths prevented by receiving the vaccine and booster.

The analysis concluded that individuals who received the vaccine, but not the booster were 11 times less likely to be hospitalized.

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In contrast, individuals who received their booster are 46 times less likely to be hospitalized.


Further analysis from Dr. Donahue and his team estimates the number of hospitalizations and deaths prevented by vaccination.

Researchers came to their conclusion by calculating the rate of hospitalizations and deaths per week among those who are not fully vaccinated in Nebraska, they then applied that data to the Nebraska population.

By applying the not fully vaccinated rate of hospitalization and death to the whole population, researchers determined the benefit vaccinations and boosters provide.1

Hospitalizations: COVID-19 hospitalizations were identified from healthcare data obtained from the State Health Information Exchange, then matched the data with Nebraska State Immunization Information System vaccination data.

This creates a weekly ratio of hospitalizations for those who were not fully vaccinated to those who were fully vaccinated.

Researchers estimate that this data source contains 60-70% of all COVID-19 hospitalizations in Nebraska.

Researchers then applied the determined ratio to incident hospitalizations identified from HHS Protect.


Deaths: Deaths were identified from Nebraska vital records death certificate data.  A death certificate is completed for all Nebraskans who die in the state.

Deaths that included COVID-19 as the immediate cause of death or a contributing cause of death were included in the analysis.

“By applying the unvaccinated rate of hospitalizations and deaths to the whole population, we have a stronger understanding of the clear and overwhelming benefit of getting vaccinated,” said Donahue.

DHHS urges all Nebraskans who have not done so already to consider getting vaccinated and receive the booster and to consult a doctor if there are questions. Please register for the vaccine at or call the hotline at 833-998-2275

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